Generation of genetically modified animal models in Southamerica. [Génération d'animaux génétiquement modifies en Amerique du Sud.]
ABSTRACT.- The generation of genetically modified animals has made possible to achieve great scientific advances in several fields. In 2006 we set up a Technological Unit at Institut Pasteur of Montevideo capable of conducting our own research program and provide researchers of Uruguay and the region with genetically modified mouse models. In 2014, we implemented the CRISPR/Cas9 system, which allowed us to broaden the scope of our activity and develop other projects involving mice and sheep, thus positioning this laboratory as a reference technological platform in South America.