ABSTRACT.- Amaranth (Amaranthus spp.) resistant to glyphosate and diclosulam represent the most important weed complex in Uruguayan agricultural systems. The objective of this study was to evaluate the use of cover crops (CC) and herbicide strategies (HS) in the management of amaranth. The work was divided into two stages, the first conducted at the field, where the use of CC and pre/post-emergent HS was evaluated. Black oat and Rye were used as CC, and 15 HS (pre and/or post-emergent) were applied to manage amaranth in soybean crops. The second study was conducted in a greenhouse, where the control of amaranth was evaluated using 15 pre-emergent HS associated with black oat or rye straw. Nine HS were also considered for post-emergent weed management. © 2024 Informa UK Limited, trading as Taylor & Francis Group.