ABSTRACT.- In highly modified agricultural settings, it is now necessary to consider the management of plant diseases, insect pests and weeds within the One Health concept, to acknowledge that the health of plants, animals, environment and people are interlinked and interdependent. Articles included in this special issue of Sociedad Uruguaya de Fitopatología contribute to communicate scientific advances that will foster the sustainable management of diseases, pests and weeds in Uruguay and neighbouring countries. Although local in the field of application, the results and conclusions of the presented works will undoubtedly attract the interest of an international audience. In support of this, we can assume that the One Health initiative that guides our work mirrors the older One World concept, which reminds us that all parts are significant in the pursuit of the common good. © 2022 Informa UK Limited, trading as Taylor & Francis Group