The maintenance of an adequate soil nutrient status is crucial for ensuring food security while avoiding nutrient imbalances, mining, or enrichment that may lead to environmental damage. In Uruguay, the traditional rice-pasture rotation, allowing for direct livestock grazing, has gradually shifted towards more intensive rotations over the last decade, primarily adopting a rice-soybean rotation. This has given rise to issues pertaining to the necessity of reviewing the fertilization strategy and assessing its long-term impact on crop yields and nutrient balances associated with these new intensive rotations.