ABSTRACT - We describe a new species of Tabanus (for Uruguay, the first in more than 90 years) based on females from the Department of Tacuarembó, Uruguay. Tabanus tacuaremboensissp. n. is the 15th species of the genus Tabanus recorded from Uruguay. The species description is accompanied by illustrations of the diagnostic external and internal characters. In addition, for comparison with the new species, we provide photographs of the regional species of Tabanus whose distributions are still poorly known. In view of the lengthy hiatus since the last new tabanid species was described from Uruguay, we offer a brief discussion of the importance of new and further sampling in areas where the tabanofauna is still poorly known. © 2022, Sociedade Entomológica do Brasil.