ABSTRACT. The chemical control of Fusarium Head Blight (FHB) using fungicide has remained an unresolved challenge worldwide. Experiments using fungicides to control the disease have shown large difference of effi ciency due to multiple factors (fungicides, moment and method of application, nozzle types, and weather conditions at the time of application, etc.) responsible for disease development. Besides adequate disease control, the fungicides are also expected to act on toxin production. Results have shown that highly susceptible cultivars cannot be fully protected under severe epidemic conditions. For this reason these cultivars need to be withdrawn from commercial production and chemical control be applied as preventive measure based on the FHB developmental models and weather forecasts. Presently one of the most effi cient fungicides to control FHB in the Southern Cone region is Metconazole followed by the Tebuconazole. Other fungicides (Prochloraz, Thiabendazole, Carbendazim, etc.) used earlier are less effi cient compared to the triazoles mentioned earlier. Under experimental conditions, nozzle types like Twinjet 60 or Turbo TeeJet Duo have shown an increase the disease control effi cacy. The earliest time to spray is after complete heading, beginning of fl owering or mid fl owering depending on the year and weather conditions. © Springer Science+Business Media Dordrecht 2013. All rights are reserved.