ABSTRACT.- Purpose of Review:This review intends to examine the role of phytochemicals in plant defense mechanisms against environmental stresses and their potential health benefits. Specifically, it aims to explore how pre-harvest insect damage can enhance the production of phytochemicals in pecan and strawberries fruits. Additionally, the review intends to examine the regulation of plant phenolics and ellagitannin derivatives through signal transduction pathways and how these pathways are influenced by biotic stresses.