ABSTRACT. There are opportunities to improve livestock family farms (LFFs) sustainability in Uruguay by using the co-innovation approach to change management practices and incorporate technologies. To harness these opportunities, between 2012 and 2015, a research project was implemented in Eastern Uruguay, where three simultaneous processes occurred at three levels: farm, region, and research team. At farm level, the work was carried out in seven LFF as case studies following three steps: (i) characterization and diagnosis; (ii) redesign; and (iii) implementation, monitoring, and evaluation. At the regional level, a participatory approach to planning, monitoring, and evaluating the project?s progress with regional stakeholders was adopted. At the team level, a Participatory Action Research approach was used. Consensus on the objectives and methods allowed for combined knowledge to solve practice-oriented problems. The 3-year project demonstrated the effectiveness in improving LFF sustainability, opened a learning space with stakeholders, and utilized a co-innovation model to improve rural development outcomes. @The Authors, 2017.